Scrabble letters IBS

A Closer Look at the Role of the Microbiome in IBS

  • Gut Health

  • By Desiree Nielsen, Registered Dietitian

    A Closer Look at the Role of the Microbiome in IBS

    Irritable bowel syndrome, with its constellation of symptoms and potential causes, is far more than a bit of stomach upset. As a disorder of gut-brain communication, IBS offers an important example of the complex interactions between the digestive, immune and nervous systems.1

    It is impossible to talk about IBS without talking about the gut microbiota, which lies at the intersection of the gut-brain-immune connection. Early research suggests that the gut microbiota of those with IBS is different from those without the condition; however, the research has yet to establish a definitive ‘fingerprint’ of the IBS microbiota.1,2 Knowing this, it is reasonable to expect that the trillions of microbes that live in the gut are an important root cause of IBS symptoms…but what does the research say? Let’s examine the role of the microbiota along the entire spectrum of risk factors to treatment.


    Microbiota as a risk factor for IBS

    Risk factors for IBS are well understood and include early life stressors, enteric infection and exposure to antibiotics; interestingly, all three of these risk factors could be reasonably expected to alter the gut microbiome.1-3 Stress is well-known to alter the gut environment and its microbiota–in fact, stress is enough to exacerbate IBS once it exists.4,6 Enteric infection is a well-defined risk factor for irritable bowel syndrome. Alterations post-infection can lead to a subcategory of IBS known as post-infectious IBS. 

    Perhaps the most intriguing connection is that antibiotics in early life are a risk factor. There remains some controversy over the plasticity of the gut microbiota post-antibiotic use. While some research suggests that the microbiota bounces back relatively quickly post-treatment, others suggest that a single course of antibiotics can alter the microbiota for months, allowing opportunistic pathogens to gain a foothold.7,8 That exposure to these routine alterations could be linked to the development of irritable bowel syndrome later on suggests that even subtle insults could lay the groundwork for a less resilient microbiome that can place digestive health at risk.


    Microbiota in symptoms of IBS

    Irritable bowel syndrome symptoms can range from mild to severe and include diarrhea or constipation, abdominal pain, along with increased gas and bloating. These symptoms can make everyday activities such as commuting to work more challenging, with a negative impact on quality of life. The nervous system is a primary driver, along with potential roles for the immune system and the microbiota.

    Let’s take a look at two primary IBS symptoms–altered motility and visceral hypersensitivity–that originate in the nervous system. Interestingly, the microbiota have been found in the research to impact both.

    Localized mucosal inflammation is known to sensitize the nervous system, with the potential to increase pain perception.4 It is suggested that gut barrier alterations in IBS may contribute to nervous system changes; gut barrier integrity is critical to maintaining a calm immune response.4,6 Inflammation can occur due to concurrent disease states, infection, dietary choices or food allergy as well as bacterial imbalances.4,6 Certain strains of bacteria, such as those from Pseudomonas or Ruminococcus species, can alter barrier function in such a way to activate the inflammatory response while the inflammatory response can alter the gut microbiota itself creating the potential for a self-sustaining feedback loop.6

    The gut microbiota also has the potential to influence the enteric nervous system directly, through short chain fatty acids, which may influence local neurotransmitter production.5 Finally, it is well established that enteric infection can alter stool quality with respect to diarrhea; however, can microbes impact constipation? The answer is yes. It is thought that methanogens, which are in fact not bacteria but hail from the domain Archaea, are associated with increased rates of functional constipation and delayed transit time in IBS.15

    In the literature, there are countless associations between the gut microbiota and potential origins of irritable bowel syndrome; however, there is a lot more to understand before some of this knowledge can change clinical practice. In the meantime, it makes sense that our gut microbiota be addressed while treating irritable bowel syndrome as long as we are aware of the potential limitations of this approach.


    Microbiota in IBS Management

    There are two major routes to altering the microbiota: influencing its composition with probiotics or with food substrates. 

    Initially, research focused on the potential of prebiotic substances such as inulin to positively influence the gut microbiota; however, in irritable bowel syndrome, it is the opposite approach that has been found useful. The low FODMAP exclusion diet omits fermentable carbohydrates that drive growth in the gut microbiota, providing symptom relief rates of approximately 50-87%.9,10 While not a great deal of research exists, what is currently known is that the low FODMAP diet decreases both the richness and diversity of the gut microbiota–which is why the diet is not recommended as a long term solution.9,10 That is helps provide symptom relief alongside altering the gut microbiota suggests that its effect on the gut microbiota at least contributes to symptom experience.

    With respect to probiotics, a large body of literature exists examining the role of probiotics in providing symptom relief in IBS. The research suffers from heterogeneity, however, systematic reviews suggest that multi-strain probiotics may hold potential.3,11,12 And there are examples of specific retail probiotics that have shown benefit, including Bio-K+ probiotics. In 2018, one trial of 113 people with IBS found that IBS is effective at reducing the number of high pain days, improving the consistency and frequency of stool, as well as quality of life* for those with IBS-D.13,14


    Taking an integrative approach to IBS

    As a dietitian, it is important to know that nutrition is an important part of managing IBS–but it is not a standalone option. As a disorder of gut-brain communication, addressing stress management is critical–as is acknowledging the role of the microbiome in the natural history of the condition. In my practice, we take an integrative approach that includes dietary change, stress management, physical activity and a probiotic such as Bio-K+ IBS Pro. 




    * IBS-QoL included an overall score and assessment of quality of life in eight validated domains: dysphoria, interference with activity, body image, health worry, food avoidance, social reaction, sexual, and relationship. 



    1. Chey, William D., Jacob Kurlander, and Shanti Eswaran. "Irritable bowel syndrome: a clinical review." JAMA9 (2015): 949-958.
    2. Pittayanon, Rapat, et al. "Gut microbiota in patients with irritable bowel syndrome—a systematic review." Gastroenterology1 (2019): 97-108.
    3. Moayyedi, Paul, et al. "Canadian Association of Gastroenterology clinical practice guideline for the management of irritable bowel syndrome (IBS)." Journal of the Canadian Association of Gastroenterology1 (2019): 6-29.
    4. Meerveld, Beverley Greenwood-Van, and Anthony C Johnson. “Mechanisms of Stress-induced Visceral Pain.” Journal of neurogastroenterology and motility 24,1 (2018): 7-18. doi:10.5056/jnm17137
    5. Khlevner, Julie et al. “Brain-Gut Axis: Clinical Implications.” Gastroenterology clinics of North America 47,4 (2018): 727-739. doi:10.1016/j.gtc.2018.07.002
    6. Chong, Pei Pei et al. “The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy.” Frontiers in microbiology 10 1136. 10 Jun. 2019, doi:10.3389/fmicb.2019.01136
    7. Becattini, Simone et al. “Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.” Trends in molecular medicine 22,6 (2016): 458-478. doi:10.1016/j.molmed.2016.04.003
    8. Rashid, Mamun-Ur, et al. "Determining the long-term effect of antibiotic administration on the human normal intestinal microbiota using culture and pyrosequencing methods." Clinical infectious diseasessuppl_2 (2015): S77-S84.
    9. Whelan, Kevin, et al. "The low FODMAP diet in the management of irritable bowel syndrome: an evidence‐based review of FODMAP restriction, reintroduction and personalisation in clinical practice." Journal of human nutrition and dietetics2 (2018): 239-255.
    10. Halmos, Emma P., and Peter R. Gibson. "Controversies and reality of the FODMAP diet for patients with irritable bowel syndrome." Journal of gastroenterology and hepatology7 (2019): 1134-1142.
    11. Liang, Ding, Ning Longgui, and Xu Guoqiang. "Efficacy of different probiotic protocols in irritable bowel syndrome: A network meta-analysis." Medicine27 (2019).
    12. Dale, Hanna Fjeldheim, et al. "Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review." Nutrients9 (2019): 2048.
    13. Preston, K., et al. "Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study." Beneficial Microbes5 (2018): 697-706
    14. Ship N, et al. Burden of IBS-Diarrhea Symptoms Tracked With Daily Journals for 12 Weeks in a Randomized, Double-Blind, Placebo-Controlled Study of Lactobacillus AcidophilusCL1285,L. CaseiLBC80R and L. RhamnosusCLR2: Am J Gastroenterol 2019 ACG Annual Meeting Abstracts P509:S296-S297
    15. Gottlieb, K et al. “Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders.” Alimentary pharmacology & therapeutics 43,2 (2016): 197-212. doi:10.1111/apt.13469




    Best Sellers


    Drinkable Vegan Probiotic

    Certified gluten-free, organic and non-GMO probiotics with a minimum of 50 billion live & active beneficial bacteria per bottle.

    Peach & Turmeric

    Extra Drinkable Probiotic

    Exclusive probiotic strains with a minimum of 80 billion live & active beneficial bacteria per bottle.

    Daily Care 25 Billion

    Vegan Probiotic Capsules

    Certified gluten-free and vegan probiotics. A great option for those who need daily support or a need a stronger alternative for better benefits.

    Desiree Nielsen Registered Dietitian
    About the author
    Desiree Nielsen is a registered dietitian, author and host of the vvegetarian ccooking sshow, The Urban Vegetarian. Desiree takes an evidence-based, integrative approach to her dietetics work, with a focus on anti-inflammatory, plant-centredcentered nutrition and digestive health.
    View all articles by Desiree Nielsen
    Back to blog